A group of teens at the Hope Juvenile Treatment Center are shocked to discover their guards have abandoned them, but their joy turns to fear when they learn a catastrophic pandemic has occurred outside their walls, turning their new-found freedom into a fight for survival.

Twelve-year-old Jonathan Grisby has been sent to the Slabhenge Reformatory School for Troubled Boys, a former lunatic asylum which is currently run by a sadist who enjoys punishing the boys and setting them against each other; but when a lightning strike kills all the adults the boys find themselves suddenly free--and trapped on Scar Island which seems to be sinking into the ocean.

After being caught stealing one too many times, Benjamin Waterfalls is sent to a "boot camp" at the Ojibwe reservation where he searches for answers as he tries to turn his life around and embrace this second chance.

As further evidence of his family's bad fortune which they attribute to a curse on a distant relative, Stanley Yelnats is sent to a hellish correctional camp in the Texas desert where he finds his first real friend, a treasure, and a new sense of himself.