While attending the Magical Congress of the United States of America in 1926, Newt Scamander is pursued by the wizarding authorities when dangerous beasts and their habitats escape from his magical briefcase.

This screenplay in book form describes the dialogue and action of the film. After Newt Scamander helps to capture Gellert Grindelwald, the criminal soon escapes custody and begins gathering followers under his ideology of keeping magic for pure-blood wizards only. Albus Dumbledore, Grindelwald's truest friend, has no choice but to resist the charismatic leader and ask Newt to help thwart the plans for (wizarding) world domination.